145040-09-1
145040-09-1
Chemical Structure
Hydrolyzed Fumonisin B1
Synonym(s): Aminopentol
- CAS No.: 145040-09-1
- Formula:C22H47NO5
- Molecular Weight:405.61
IUPAC Name: (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentaol
InChIKey: UWWVLQOLROBFTD-GADKELDLSA-N
SMILES: C[C@H](N)[C@@H](O)C[C@H](O)CCCC[C@@H](O)C[C@H](C)C[C@H](O)[C@H](O)[C@H](C)CCCC
Biological Activity: Hydrolyzed Fumonisin B1 (Aminopentol) is the backbone and main hydrolysis product of the mycotoxin Fumonisin B1 (HY-N6719). Hydrolyzed Fumonisin B1 can weakly inhibit ceramide synthase[1][2][3].
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Hydrolyzed Fumonisin B1 | Hydrolyzed Fumonisin B1 (Aminopentol) is the backbone and main hydrolysis product of the mycotoxin Fumonisin B1 (HY-N6719). Hydrolyzed Fumonisin B1 can weakly inhibit ceramide synthase. | |||||||||||||||||||||
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References
- [1]. Collins TF, et al. Effects of aminopentol on in utero development in rats. Food Chem Toxicol. 2006 Feb;44(2):161-9. [Content Brief]
- [2]. Humpf HU, et al. Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor. J B [Content Brief]
- [3]. Schmelz EM, et al. Induction of apoptosis by fumonisin B1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases. Toxicol Appl Pharmacol. 1998 Feb;148(2):252-60. [Content Brief]
