1458031-48-5
1458031-48-5
Chemical Structure
RUSKI-201
- CAS No.: 1458031-48-5
- Formula:C20H27N3OS
- Molecular Weight:357.51
IUPAC Name: 2-((2-methylbutyl)amino)-1-(4-(6-methylpyridin-2-yl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethan-1-one
InChIKey: KYOIGHSNTIJBPW-UHFFFAOYSA-N
SMILES: CCC(C)CNCC(N1CCC2=C(C=CS2)C1C3=NC(C)=CC=C3)=O
Biological Activity: RUSKI-201 is a potent and specific Hedgehog acyltransferase (Hhat) inhibitor, with an IC50 of 0.20 μM. RUSKI-201 is able to block Hh signaling from Shh overexpressing cells and inhibits Hh palmitoylation. RUSKI-201 is potential Hhat chemical probe in cells and can used in studies of Hhat catalytic function[1].
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RUSKI-201 | RUSKI-201 is a potent and specific Hedgehog acyltransferase (Hhat) inhibitor, with an IC50 of 0.20 μM. RUSKI-201 is able to block Hh signaling from Shh overexpressing cells and inhibits Hh palmitoylation. RUSKI-201 is potential Hhat chemical probe in cells and can used in studies of Hhat catalytic function. | |||||||||||||||||||||
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