146797-82-2
Chemical Structure
Arachidonoyl thio-PC
- CAS No.: 146797-82-2
- Formula:C44H82NO6PS
- Molecular Weight:784.16
IUPAC Name: (R)-3-(hexadecyloxy)-2-(((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl)thio)propyl (2-(trimethylammonio)ethyl) phosphate
InChIKey: YDSCLGYBUIDZNF-WWBBCYQPSA-N
SMILES: [C@H](SC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)(COP(OCC[N+](C)(C)C)(=O)[O-])COCCCCCCCCCCCCCCCC
Biological Activity: Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.
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Arachidonoyl thio-PC | Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay. | |||||||||||||||||||||
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