146929-33-1
Chemical Structure
Cyclazosin hydrochloride
- CAS No.: 146929-33-1
- Formula:C23H28ClN5O4
- Molecular Weight:473.95
IUPAC Name: ((4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)octahydroquinoxalin-1(2H)-yl)(furan-2-yl)methanone hydrochloride
InChIKey: SKDIDWRQDBIQBS-MCJVGQIASA-N
SMILES: COC1=CC2=NC(N3CCN(C(C4=CC=CO4)=O)[C@@]5([H])CCCC[C@@]35[H])=NC(N)=C2C=C1OC.Cl
Biological Activity: Cyclazosin hydrochloride is an α1B-adrenergic receptor antagonist. Cyclazosin hydrochloride has high specificity for α-adrenergic receptors, with pKi values of 9.23-9.57 and 8.18-8.41 for O/1A (O/la) and OflB (alb) adrenergic receptors, respectively. However, Cyclazosin hydrochloride cannot distinguish between cloned alb and alo adrenergic receptors, which have pKi values of 9.23 and 9.28, respectively[1].
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Cyclazosin hydrochloride | Cyclazosin hydrochloride is an α1B-adrenergic receptor antagonist. Cyclazosin hydrochloride has high specificity for α-adrenergic receptors, with pKi values of 9.23-9.57 and 8.18-8.41 for O/1A (O/la) and OflB (alb) adrenergic receptors, respectively. However, Cyclazosin hydrochloride cannot distinguish between cloned alb and alo adrenergic receptors, which have pKi values of 9.23 and 9.28, respectively. | |||||||||||||||||||||
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Keywords
