1471479-22-7
Chemical Structure
TLD-1433
- CAS No.: 1471479-22-7
- Formula:C49H38Cl2N8RuS3
- Molecular Weight:1007.05
InChIKey: AVOZSOCUVHJHTQ-UHFFFAOYSA-L
SMILES: CC1=CC=[N](C2=C1)[Ru+2]([N]3=CC=C4)([N](C5=C6)=CC=C6C)([N](C5=C7)=CC=C7C)([N](C2=C8)=CC=C8C)[N]9=CC=CC%10=C9C3=C4C%11=C%10NC(C%12=CC=C(C%13=CC=C(C%14=CC=CS%14)S%13)S%12)=N%11.[Cl-].[Cl-]
Biological Activity: TLD-1433 is the fourth-generation ruthenium (II) based photodynamic compound (PDC). TLD-1433 is activated by green light (525 ± 25 nm) and efficiently generates ROS to achieve pathogen inactivation. After photoinactivation, TLD-1433 significantly induces lipid peroxidation of the cell membrane, which can directly damage the integrity of the viral envelope. TLD-1433 has ID50 for enveloped viruses (such as H1N1 influenza virus, coronavirus OC43, HSV-1, Zika virus) is as low as nanomolar level; for non-enveloped viruses (such as adenovirus Ad5, mammalian rotavirus MRV), a concentration of micro-molar level is required for inactivation. TLD-1433 has antigen retention property and can be used for the preparation of inactivated vaccines[1].
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TLD-1433 | TLD-1433 is the fourth-generation ruthenium (II) based photodynamic compound (PDC). TLD-1433 is activated by green light (525 ± 25 nm) and efficiently generates ROS to achieve pathogen inactivation. After photoinactivation, TLD-1433 significantly induces lipid peroxidation of the cell membrane, which can directly damage the integrity of the viral envelope. TLD-1433 has ID50 for enveloped viruses (such as H1N1 influenza virus, coronavirus OC43, HSV-1, Zika virus) is as low as nanomolar level; for non-enveloped viruses (such as adenovirus Ad5, mammalian rotavirus MRV), a concentration of micro-molar level is required for inactivation. TLD-1433 has antigen retention property and can be used for the preparation of inactivated vaccines. | |||||||||||||||||||||
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Keywords
