147696-46-6
147696-46-6
Chemical Structure
ZD-6169
- CAS No.: 147696-46-6
- Formula:C17H14F3NO3
- Molecular Weight:337.29
IUPAC Name: (S)-N-(4-benzoylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide
InChIKey: LVEDGSIMCSQNNX-INIZCTEOSA-N
SMILES: O=C(NC1=CC=C(C(C2=CC=CC=C2)=O)C=C1)[C@](C)(O)C(F)(F)F
Biological Activity: ZD-2767 is a selective ATP-sensitive potassium channel agonist. ZD-276 reduces cell membrane excitability and contractility by activating KATP channels in bladder smooth muscle. ZD-2767 is promising for research of overactive bladder[1].
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ZD-6169 | ZD-2767 is a selective ATP-sensitive potassium channel agonist. ZD-276 reduces cell membrane excitability and contractility by activating KATP channels in bladder smooth muscle. ZD-2767 is promising for research of overactive bladder. | |||||||||||||||||||||
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References
- [1]. Fryer RM, et al. (-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a novel ATP-sensitive potassium channel opener: hemodynamic comparison to ZD-6169, WAY-133537, and nifedipine in the anesthetized canine. J Cardiovasc Pharmacol. 2004 Aug;44(2):137-47. [Content Brief]
