1477-67-4
Chemical Structure
Pregnanolone sulfate
- CAS. Nr.: 1477-67-4
- Formula:C21H34O5S
- Molecular Weight:398.56
IUPAC Name: (3R,5R,8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl hydrogen sulfate
InChIKey: MENQCIVHHONJLU-YZRLXODZSA-N
SMILES: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@H](C(C)=O)CC4)[H])(CC[C@@]1(C[C@H](OS(=O)(=O)O)CC2)[H])[H])[H]
Biological Activity: Pregnanolone sulfate is an endogenous neurosteroid and NMDA receptor inhibitor. Pregnanolone sulfate exhibits stronger inhibition of tonically activated NMDA receptors (associated with excitotoxicity) than of phasically activated synaptic receptors. Pregnanolone sulfate enhances glutamate release. Pregnanolone sulfate can be used in research on excitotoxic neurodegenerative diseases[1][2][3].
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Pregnanolone sulfate | Pregnanolone sulfate is an endogenous neurosteroid and NMDA receptor inhibitor. Pregnanolone sulfate exhibits stronger inhibition of tonically activated NMDA receptors (associated with excitotoxicity) than of phasically activated synaptic receptors. Pregnanolone sulfate enhances glutamate release. Pregnanolone sulfate can be used in research on excitotoxic neurodegenerative diseases. | |||||||||||||||||||||
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References
- [1]. Smejkalova T, et al. Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms. British journal of pharmacology. 2021 Oct;178(19):3888-3904. [Content Brief]
- [2]. Chvojkova M, et al. Synthetic structural modifications of neurosteroid pregnanolone sulfate: Assessment of neuroprotective effects in vivo. European journal of pharmacology. 2020 Aug 15;881:173187.
- [3]. Kussius CL, et al. Pregnanolone sulfate promotes desensitization of activated NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 May 27;29(21):6819-27.
