148089-70-7
148089-70-7
Chemical Structure
S-15176
- CAS. Nr.: 148089-70-7
- Formula:C31H48N2O4S
- Molecular Weight:544.79
InChIKey: GMNFEHDZQAODON-UHFFFAOYSA-N
SMILES: OC1=C(C(C)(C)C)C=C(SCCCN2CCN(CC2)CC3=CC=C(C(OC)=C3OC)OC)C=C1C(C)(C)C
Biological Activity: S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP). S-15176 inhibits mitochondrial swelling induced by tert-butylhydroperoxide with an IC50 value of 45.7 μM. S-15176 inhibits PTP opening, prevents mitochondrial membrane potential dissipation and NAD(P)H oxidation, and increases mitochondrial calcium loading capacity. S-15176 is promising for research of ischemia-reperfusion injury[1][2].
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S-15176 | S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP). S-15176 inhibits mitochondrial swelling induced by tert-butylhydroperoxide with an IC50 value of 45.7 μM. S-15176 inhibits PTP opening, prevents mitochondrial membrane potential dissipation and NAD(P)H oxidation, and increases mitochondrial calcium loading capacity. S-15176 is promising for research of ischemia-reperfusion injury. | |||||||||||||||||||||
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References
- [1]. Albengres E, et al. S15176 and S16950 interaction with Cyclosporin A antiproliferative effect on cultured human lymphocytes. Fundam Clin Pharmacol. 2001 Feb;15(1):41-6. [Content Brief]
- [2]. Elimadi A, et al. S-15176 inhibits mitochondrial permeability transition via a mechanism independent of its antioxidant properties. Eur J Pharmacol. 2003 May 9;468(2):93-101. [Content Brief]
