148201-60-9
148201-60-9
Chemical Structure
A-74932 hydrochloride
- CAS No.: 148201-60-9
- Formula:C25H26ClFN4O5
- Molecular Weight:516.95
IUPAC Name: 6-(2-(2-aminopentanamido)pyrrolidin-1-yl)-5-fluoro-3-oxo-3H-pyrido[3,2,1-kl]phenoxazine-2-carboxylic acid hydrochloride
InChIKey: UFBYBJURMXBKFU-UHFFFAOYSA-N
SMILES: O=C(C1=CN2C3=C(C(N4C(NC(C(N)CCC)=O)CCC4)=C(F)C=C3C1=O)OC5=CC=CC=C25)O.Cl
Biological Activity: A-74932 hydrochloride is a potent Top II inhibitor with antitumor activity. A-74932 hydrochloride inhibits the catalytic activity of mammalian DNA topoisomerase II. A-74932 hydrochloride can be used for cancer research[1][2].
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A-74932 hydrochloride | A-74932 hydrochloride is a potent Top II inhibitor with antitumor activity. A-74932 hydrochloride inhibits the catalytic activity of mammalian DNA topoisomerase II. A-74932 hydrochloride can be used for cancer research. | |||||||||||||||||||||
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References
- [1]. Snyder RD. Use of catalytic topoisomerase II inhibitors to probe mechanisms of chemical-induced clastogenicity in Chinese hamster V79 cells. Environ Mol Mutagen. 2000;35(1):13-21. [Content Brief]
- [2]. Permana PA, et al. Quinobenoxazines: a class of novel antitumor quinolones and potent mammalian DNA topoisomerase II catalytic inhibitors. Biochemistry. 1994 Sep 20;33(37):11333-9. [Content Brief]
