1492-08-6
Chemical Structure
Mevalonic acid 5-diphosphate
Synonym(s): MVAPP
- CAS No.: 1492-08-6
- Formula:C6H14O10P2
- Molecular Weight:308.12
InChIKey: SIGQQUBJQXSAMW-UHFFFAOYSA-N
SMILES: O=C(CC(C)(CCOP(O)(OP(O)(O)=O)=O)O)O
Biological Activity: Mevalonic acid 5-diphosphate (MVAPP) is a metabolic intermediate in the mevalonate pathway. Mevalonic acid 5-diphosphate inhibits rat MVK as a substrate analog with an IC50 of 180 µM. Mevalonic acid 5-diphosphate serves as a substrate/phosphate acceptor for hMDD and undergoes ATP-dependent decarboxylation to generate isopentenyl diphosphate and DMAPP (HY-130573), with a human Km of 28.9 μM. Mevalonic acid 5-diphosphate can be used for research on Enterococcus infections[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Mevalonic acid 5-diphosphate | Mevalonic acid 5-diphosphate (MVAPP) is a metabolic intermediate in the mevalonate pathway. Mevalonic acid 5-diphosphate inhibits rat MVK as a substrate analog with an IC50 of 180 µM. Mevalonic acid 5-diphosphate serves as a substrate/phosphate acceptor for hMDD and undergoes ATP-dependent decarboxylation to generate isopentenyl diphosphate and DMAPP (HY-130573), with a human Km of 28.9 μM. Mevalonic acid 5-diphosphate can be used for research on Enterococcus infections. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Qiu Y, et al. Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. Organic letters. 2006 Mar 16;8(6):1013-6.
- [2]. Hsieh MH, et al. The Arabidopsis IspH homolog is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. Plant physiology. 2005 Jun;138(2):641-53.
- [3]. Song N, et al. An ERF2-like transcription factor regulates production of the defense sesquiterpene capsidiol upon Alternaria alternata infection. Journal of experimental botany. 2019 Oct 24;70(20):5895-5908.
- [4]. Tomescu MS. In-Field and in Silico Bioprospecting for Hydroxynitrile Lyases and Terpenoid Synthases from Flora in South Africa (Doctoral dissertation, et al.
- [5]. Voynova NE, et al. Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. Archives of biochemistry and biophysics. 2008 Dec 01;480(1):58-67. [Content Brief]
- [6]. Chen CL, et al. Mevalonate 5-diphosphate mediates ATP binding to the mevalonate diphosphate decarboxylase from the bacterial pathogen Enterococcus faecalis. J Biol Chem. 2017 Dec 29;292(52):21340-21351.
