14957-38-1
Chemical Structure
Marmin
- CAS No.: 14957-38-1
- Formula:C19H24O5
- Molecular Weight:332.39
IUPAC Name: (R,E)-7-((6,7-dihydroxy-3,7-dimethyloct-2-en-1-yl)oxy)-2H-chromen-2-one
InChIKey: QYYKWTUUCOTGNS-JIIJFUIFSA-N
SMILES: CC(C)(O)[C@H](O)CC/C(C)=C/COC1=CC=C(C=CC2=O)C(O2)=C1
Biological Activity: Marmin is a histamine receptor inhibitor and tracheal smooth muscle relaxant. Marmin antagonizes histamine- and methacholine-induced contraction of tracheal smooth muscle. Marmin inhibits histamine release from mast cells, and also blocks extracellular calcium influx via voltage-dependent calcium channels as well as calcium release from intracellular calcium stores, thereby effectively inhibiting calcium-mediated smooth muscle contraction. Marmin slightly enhances the relaxant effect of isoprenaline, and induces epithelial-dependent tracheal smooth muscle relaxation independent of nitric oxide, cGMP or β2-adrenergic pathways through the release of prostaglandin E2[1][2].
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Marmin | 99.40% | Marmin is a histamine receptor inhibitor and tracheal smooth muscle relaxant. Marmin antagonizes histamine- and methacholine-induced contraction of tracheal smooth muscle. Marmin inhibits histamine release from mast cells, and also blocks extracellular calcium influx via voltage-dependent calcium channels as well as calcium release from intracellular calcium stores, thereby effectively inhibiting calcium-mediated smooth muscle contraction. Marmin slightly enhances the relaxant effect of isoprenaline, and induces epithelial-dependent tracheal smooth muscle relaxation independent of nitric oxide, cGMP or β2-adrenergic pathways through the release of prostaglandin E2. | ||||||||||||||||||||
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- [1]. Nugroho AE, et al. Effects of marmin, a compound isolated from Aegle marmelos Correa, on contraction of the guinea pig-isolated trachea. Pakistan journal of pharmaceutical sciences. 2011 Oct;24(4):427-33. [Content Brief]
- [2]. Husori D I, et al. Relaxation effect of marmin on guinea pig tracheal smooth muscle via NO-independent mechanisms[J]. Asian Pacific Journal of Tropical Disease, 2012, 2: S154-S158.
Keywords
