149709-63-7
149709-63-7
Chemical Structure
(2S,4S)-Sacubitril
- CAS No.: 149709-63-7
- Formula:C24H29NO5
- Molecular Weight:411.49
IUPAC Name: 4-(((2S,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid
InChIKey: PYNXFZCZUAOOQC-UWJYYQICSA-N
SMILES: [H]N(C(CCC(O)=O)=O)[C@H](CC(C=C1)=CC=C1C2=CC=CC=C2)C[C@@H](C(OCC)=O)C
Biological Activity: (2S,4S)-Sacubitril is the impurity of Sacubitril. Sacubitril is a potent NEP inhibitor that can be used for the research of heart failure[1][2].
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(2S,4S)-Sacubitril | (2S,4S)-Sacubitril is the impurity of Sacubitril. Sacubitril is a potent NEP inhibitor that can be used for the research of heart failure. | |||||||||||||||||||||
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(2S,4S)-Sacubitril-d4 | (2S,4S)-Sacubitril-d4 is deuterium labeled (2S,4S)-Sacubitril. (2S,4S)-Sacubitril is the impurity of Sacubitril. Sacubitril is a potent NEP inhibitor that can be used for the research of heart failure. | |||||||||||||||||||||
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References
- [1]. Halama A, et, al. Synthesis, Isolation, and Analysis of Stereoisomers of Sacubitril. Org. Process Res. Dev. 2019, 23, 1, 102-107.
- [2]. Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9. [Content Brief]
