1507362-06-2
1507362-06-2
Chemical Structure
TNKS-IN-4
- CAS No.: 1507362-06-2
- Formula:C24H24N4O3S
- Molecular Weight:448.54
IUPAC Name: N-((1r,4r)-4-(4-cyanophenoxy)cyclohexyl)-3-((4-oxo-1,4-dihydroquinazolin-2-yl)thio)propanamide
InChIKey: MCMCBDOVNWSRNM-UAPYVXQJSA-N
SMILES: O=C1C2=CC=CC=C2NC(SCCC(N[C@@H]3CC[C@@H](OC4=CC=C(C#N)C=C4)CC3)=O)=N1
Biological Activity: TNKS-IN-4 (compound 49) is an orally active tankyrase (TNKS) inhibitor with IC50 values of 0.1 nM and 7.6nM for TNKS1 and TNKS2, respectively. TNKS-IN-4 can be used for study of APC-mutant colorectal cancer[1].
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TNKS-IN-4 | TNKS-IN-4 (compound 49) is an orally active tankyrase (TNKS) inhibitor with IC50 values of 0.1 nM and 7.6nM for TNKS1 and TNKS2, respectively. TNKS-IN-4 can be used for study of APC-mutant colorectal cancer. | |||||||||||||||||||||
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References
Keywords
