152468-44-5
Chemical Structure
GAD65 (524-543)
- CAS No.: 152468-44-5
- Formula:C97H168N28O28S2
- Molecular Weight:2238.67
InChIKey: ZYTDAUMVRZWQAV-QIWUVYCYSA-N
SMILES: OC(C=C1)=CC=C1C[C@@H](C(NCC(N[C@@H]([C@H](O)C)C(N[C@H](C(O)=O)[C@H](O)C)=O)=O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCSC)NC([C@H](CCSC)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)NC([C@H]2N(CCC2)C([C@H](C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](N)CO)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: GAD65 (524-543) is a biological active peptide with amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). GAD65 (524-543) is one of the first fragments of islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. GAD65 (524-543) is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells[1].
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GAD65 (524-543) | GAD65 (524-543) is a biological active peptide with amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). GAD65 (524-543) is one of the first fragments of islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. GAD65 (524-543) is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells. | |||||||||||||||||||||
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