152971-79-4
Chemical Structure
CGS-25015
- CAS. Nr.: 152971-79-4
- Formula:C17H16F3NO3S
- Molecular Weight:371.37
IUPAC Name: 3-(naphthalen-1-yl)-2-(3,3,3-trifluoro-2-(mercaptomethyl)propanamido)propanoic acid
InChIKey: VHNKNFNSIIVFBL-UHFFFAOYSA-N
SMILES: O=C(O)C(NC(=O)C(CS)C(F)(F)F)CC1=CC=CC=2C=CC=CC21
Biological Activity: CGS-25015 is a mercapto-containing metalloprotease inhibitor that inhibits endothelin-converting enzyme (ECE). CGS-25015 inhibits ECE activity with an IC50 of 2.6 μM in porcine coronary artery smooth muscle preparations, and an IC50 of 18 μM in partially purified porcine aortic endothelial cell ECE preparations. CGS-25015 inhibits endothelin production and the resulting vascular smooth muscle contractile response[1].
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CGS-25015 | CGS-25015 is a mercapto-containing metalloprotease inhibitor that inhibits endothelin-converting enzyme (ECE). CGS-25015 inhibits ECE activity with an IC50 of 2.6 μM in porcine coronary artery smooth muscle preparations, and an IC50 of 18 μM in partially purified porcine aortic endothelial cell ECE preparations. CGS-25015 inhibits endothelin production and the resulting vascular smooth muscle contractile response. | |||||||||||||||||||||
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