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Cat. No.: HY-187624

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CGS-25015

CGS-25015 is a mercapto-containing metalloprotease inhibitor that inhibits endothelin-converting enzyme (ECE). CGS-25015 inhibits ECE activity with an IC₅₀ of 2.6 μM in porcine coronary artery smooth muscle preparations, and an IC₅₀ of 18 μM in partially purified porcine aortic endothelial cell ECE preparations. CGS-25015 inhibits endothelin production and the resulting vascular smooth muscle contractile response.

For research use only. We do not sell to patients.

CAS No.: 152971-79-4
Formula: C₁₇H₁₆F₃NO₃S
Molecular Weight:371.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CGS-25015 Chemical Structure

CAS No.: 152971-79-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All MMP Isoforms :

In Vitro

ECE purified from BECs specifically hydrolyzes human big ET-1_16-38 but not human big ET-1_1-31 or human big ET-1_17-26^[1].
ECE purified from PAECs cleaves human big ET-1_16-38 at a rate 2.7-times greater than the authentic substrate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 152971-79-4
Molecular Weight 371.37
Formula C₁₇H₁₆F₃NO₃S
SMILES

O=C(O)C(NC(=O)C(CS)C(F)(F)F)CC1=CC=CC=2C=CC=CC21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Balwierczak JL, et al. Effects of metalloprotease inhibitors on smooth muscle endothelin-converting enzyme activity. Biochem Pharmacol. 1995 Jan 31;49(3):291-6.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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