15327-37-4
15327-37-4
Chemical Structure
St 587
- CAS No.: 15327-37-4
- Formula:C10H9ClF3N3
- Molecular Weight:263.65
InChIKey: WIAICRSVMJHHJL-UHFFFAOYSA-N
SMILES: FC(F)(C1=CC=C(C(NC2=NCCN2)=C1)Cl)F
Biological Activity: St 587 is a centrally acting α1-adrenoceptor agonist with an IC50 of 470 nM for rat α1-adrenoceptors. St 587 activates vascular postsynaptic α1-adrenoceptors, causing extracellular calcium influx-dependent vasoconstriction and pressor responses, and stimulates the hindlimb flexor reflex. St 587 can be used for research on neurological diseases[1][2][3][4][5][6][7][8][9][10].
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St 587 | St 587 is a centrally acting α1-adrenoceptor agonist with an IC50 of 470 nM for rat α1-adrenoceptors. St 587 activates vascular postsynaptic α1-adrenoceptors, causing extracellular calcium influx-dependent vasoconstriction and pressor responses, and stimulates the hindlimb flexor reflex. St 587 can be used for research on neurological diseases. | |||||||||||||||||||||
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References
- [1]. Maj J, et al. Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and dopaminergic functions. Journal of neural transmission. 1987 Mar;70(1):1-7. [Content Brief]
- [2]. Illes P, et al. Electrophysiological evidence for an alpha 2-adrenergic inhibitory control of transmitter release in the rabbit mesenteric artery. Eur J Pharmacol. 1987 Nov 10;143(2):151-61. [Content Brief]
- [3]. Timmermans PB, et al. Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists. J Med Chem. 1984 Apr;27(4):495-503. [Content Brief]
- [4]. Puumala T, et al. Stimulation and blockade of α1 adrenoceptors affect behavioural activity, but not spatial working memory assessed by delayed non-matching to position task in rats. Journal of Psychopharmacology. 1997 Jan;11(1):45-51. [Content Brief]
- [5]. Van der Laan JW, et al. The effects of centrally acting adrenergic agonists on temperature and on explorative and motor behaviour. Relation with effects on quasi-morphine withdrawal behaviour. European journal of pharmacology. 1985 Jan 08;107(3):367-73. [Content Brief]
- [6]. Timmermans PB, et al. Differential effect of calcium entry blockers on alpha 1-adrenoceptor-mediated vasoconstriction in vivo. Naunyn Schmiedebergs Arch Pharmacol. 1983 Dec;324(4):239-45. [Content Brief]
- [7]. Jonge AD, et al. A lipophilic, selective alpha1 -adrenoceptor agonist: 2-(2-chloro-5-trifluoromethylphenylimino)imida-zolidine (St 587). Life Sci. 1981 May 4;28(18):2009-16. [Content Brief]
- [8]. Pussinen R, et al. Effects of D-cycloserine, a positive modulator of N-methyl-D-aspartate receptors, and ST 587, a putative alpha-1 adrenergic agonist, individually and in combination, on the non-delayed and delayed foraging behaviour of rats assessed in the radial arm maze. Journal of psychopharmacology (Oxford, England). 1999;13(2):171-9. [Content Brief]
- [9]. Puumala T, et al. Effects of St-587 and prazosin on water maze and passive avoidance performance of scopolamine-treated rats. Pharmacology, biochemistry, and behavior. 1996 Sep;55(1):107-15. [Content Brief]
- [10]. Loomis CW, et al. Intrathecal St-587: effects on nociceptive reflexes and blood pressure in the rat. The Journal of pharmacology and experimental therapeutics. 1992 Nov;263(2):428-35. [Content Brief]
