1537859-24-7
1537859-24-7
Chemical Structure
GNE-3500
- CAS No.: 1537859-24-7
- Formula:C24H30FN3O3S
- Molecular Weight:459.58
IUPAC Name: 1-(4-(3-fluoro-4-(((3S,6R)-3-methyl-1,1-dioxido-6-phenyl-1,2-thiazinan-2-yl)methyl)phenyl)piperazin-1-yl)ethanone
InChIKey: WLCIIQPUMOJJOF-MHECFPHRSA-N
SMILES: FC1=CC(N2CCN(C(C)=O)CC2)=CC=C1CN3[C@@H](C)CC[C@H](C4=CC=CC=C4)S3(=O)=O
Biological Activity: GNE-3500 is a selective, orally active antagonist for Retinoic Acid Receptor-Related Orphan Receptor C (RORc, also known as RORγ or NR1F3) with an EC50 of 12 nM. GNE-3500 exhibits good pharmacokinetic characteristics in rats[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GNE-3500 | 98.90% | GNE-3500 is a selective, orally active antagonist for Retinoic Acid Receptor-Related Orphan Receptor C (RORc, also known as RORγ or NR1F3) with an EC50 of 12 nM. GNE-3500 exhibits good pharmacokinetic characteristics in rats. | ||||||||||||||||||||
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References
- [1]. Fauber BP, et al., Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) inverse agonist. J Med Chem. 2015 Jul 9;58(13):5308-22. [Content Brief]
