155180-53-3
Chemical Structure
RU 59063
- CAS No.: 155180-53-3
- Formula:C17H18F3N3O2S
- Molecular Weight:385.40
IUPAC Name: 4-(3-(4-hydroxybutyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile
InChIKey: FIDNKDVRTLFETI-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(C=C1C(F)(F)F)N(C2=O)C(N(C2(C)C)CCCCO)=S
Biological Activity: RU 59063 is an N-substituted arylthiohydantoin compound with antiandrogenic activity and high relative binding affinity for the rat androgen receptor. RU 59063 is a nonsteroidal androgen receptor that functions as a radioactive AR radioprobe (Ki: 0.71 nM, rAR) when its trifluoromethyl group is replaced by a similar hydrophobic iodine atom[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
RU 59063 | 98.61% | RU 59063 is an N-substituted arylthiohydantoin compound with antiandrogenic activity and high relative binding affinity for the rat androgen receptor. RU 59063 is a nonsteroidal androgen receptor that functions as a radioactive AR radioprobe (Ki: 0.71 nM, rAR) when its trifluoromethyl group is replaced by a similar hydrophobic iodine atom. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Teutsch G, et al. Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor. J Steroid Biochem Mol Biol. 1994 Jan;48(1):111-9. [Content Brief]
- [2]. Van Dort ME, et al. Design, synthesis, and pharmacological characterization of 4-[4, 4-dimethyl-3-(4-hydroxybutyl)-5-oxo-2-thioxo-1-imidazolidinyl]- 2-iodobenzonitrile as a high-affinity nonsteroidal androgen receptor ligand. J Med Chem. 2000 Aug 24;43(17):3344-7. [Content Brief]
Keywords
