157752-20-0
157752-20-0
Chemical Structure
CB-64D
- CAS No.: 157752-20-0
- Formula:C22H23NO2
- Molecular Weight:333.42
IUPAC Name: (1R,5R)-8-((E)-benzylidene)-5-(3-hydroxyphenyl)-2-methyl-2-azabicyclo[3.3.1]nonan-7-one
InChIKey: YVMTWTZIAIUURI-VQSNLYSRSA-N
SMILES: O=C1C[C@@]2(C3=CC=CC(O)=C3)CCN(C)[C@@](C2)([H])/C1=C\C4=CC=CC=C4
Biological Activity: CB-64D is the agonist for sigma receptor 2 and sigma receptor 1 with Ki of 16.5 and 3063 nM. CB-64D induces apoptosis in cancer cell SK-N-SH[1][2].
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CB-64D | CB-64D is the agonist for sigma receptor 2 and sigma receptor 1 with Ki of 16.5 and 3063 nM. CB-64D induces apoptosis in cancer cell SK-N-SH. | |||||||||||||||||||||
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References
- [1]. Nicholson H, et al., Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity. J Pharmacol Exp Ther. 2015 Aug;354(2):203-12. [Content Brief]
- [2]. Bowen WD, et al., CB-64D and CB-184: ligands with high sigma 2 receptor affinity and subtype selectivity. Eur J Pharmacol. 1995 May 24;278(3):257-60. [Content Brief]
Keywords
