1590379-85-3
Chemical Structure
SW43
- CAS No.: 1590379-85-3
- Formula:C27H45N3O3
- Molecular Weight:459.66
IUPAC Name: 9-(10-aminodecyl)-9-azabicyclo[3.3.1]nonan-3-yl (2-methoxy-5-methylphenyl)carbamate
InChIKey: FMRDSKZJHMVPGI-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(C)=CC=C1OC)OC2CC3N(C(C2)CCC3)CCCCCCCCCCN
Biological Activity: SW43 is a Sigma-2 selective ligand and agonist. SW43 is an ideal molecule for the development of cancer-targeted drug compounds. SW43 conjugated with DOX-L-NETA (89Y) exhibits antitumor activity in a VX2 cancer liver tumor allograft rabbit model. SW 43 conjugated with SW IV-52s to form SW III-123 activates the NF-κB pathway, has potent cytotoxicity against ovarian cancer cell lines, and induces apoptosis[1][2].
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SW43 | SW43 is a Sigma-2 selective ligand and agonist. SW43 is an ideal molecule for the development of cancer-targeted drug compounds. SW43 conjugated with DOX-L-NETA (89Y) exhibits antitumor activity in a VX2 cancer liver tumor allograft rabbit model. SW 43 conjugated with SW IV-52s to form SW III-123 activates the NF-κB pathway, has potent cytotoxicity against ovarian cancer cell lines, and induces apoptosis. | |||||||||||||||||||||
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- [1]. Ludwig JM, et al. Targeted Yttrium 89-Doxorubicin Drug-Eluting Bead-A Safety and Feasibility Pilot Study in a Rabbit Liver Cancer Model. Mol Pharm. 2017 Aug 7;14(8):2824-2830. [Content Brief]
- [2]. Zeng C, et al. Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer. Br J Cancer. 2013 Oct 29;109(9):2368-77. [Content Brief]
Keywords
