159507-82-1
Chemical Structure
MOG (92–106), mouse, rat
- CAS No.: 159507-82-1
- Formula:C80H105N21O27S
- Molecular Weight:1824.88
InChIKey: DXDCKUPARGLTIX-HOGNHCGESA-N
SMILES: OC(C=C1)=CC=C1C[C@H](NC(CNC(CNC([C@H](CCC(O)=O)NC([C@@H](N)CC(O)=O)=O)=O)=O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CS)C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(O)=O)CCC(N)=O)=O)CC3=CC=C(C=C3)O)=O)=O)CC4=CN=CN4)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O
Biological Activity: MOG (92-106), mouse, rat is a 15-peptide encephalitogenic epitope composed of amino acid residues 92-106 of myelin oligodendrocyte glycoprotein (MOG). MOG (92-106), mouse, rat serves as an I-As-restricted CD4+ T cell antigen. MOG (92-106), mouse, rat also induces extensive B cell responses against secondary myelin antigens such as MBP and PLP. MOG (92-106), mouse, rat is applicable to studies on multiple sclerosis, EAE, autoimmune demyelination, and antigen-specific T/B cell responses[1][2][3].
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MOG (92–106), mouse, rat | MOG (92-106), mouse, rat is a 15-peptide encephalitogenic epitope composed of amino acid residues 92-106 of myelin oligodendrocyte glycoprotein (MOG). MOG (92-106), mouse, rat serves as an I-As-restricted CD4+ T cell antigen. MOG (92-106), mouse, rat also induces extensive B cell responses against secondary myelin antigens such as MBP and PLP. MOG (92-106), mouse, rat is applicable to studies on multiple sclerosis, EAE, autoimmune demyelination, and antigen-specific T/B cell responses. | |||||||||||||||||||||
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References
- [1]. Bischof F, et al. A structurally available encephalitogenic epitope of myelin oligodendrocyte glycoprotein specifically induces a diversified pathogenic autoimmune response. Journal of immunology (Baltimore, Md. : 1950). 2004 Jul 01;173(1):600-6. [Content Brief]
- [2]. Tsunoda I, et al. Antibody association with a novel model for primary progressive multiple sclerosis: induction of relapsing-remitting and progressive forms of EAE in H2s mouse strains. Brain pathology (Zurich, Switzerland). 2000 Jul;10(3):402-18. [Content Brief]
- [3]. Pöllinger B, et al. Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. The Journal of experimental medicine. 2009 Jun 08;206(6):1303-16. [Content Brief]
