1600543-88-1
Chemical Structure
Huwentoxin XVI
- CAS No.: 1600543-88-1
- Formula:C196H292N50O56S6
- Molecular Weight:4437.13
SMILES: O=C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CNC=N3)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@H]8CC9=CC=C(C=C9)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%10=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N%11[C@@H](CCC%11)C(N[C@@H](CCCNC(N)=N)C(N[C@H]%12CSSC[C@@H](C(N[C@@H](CC%13=CC=C(C=C%13)O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)NC8=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CSSC[C@@H](C(N[C@@H](CO)C(NCC(N[C@@H](CC(C)C)C(N[C@H]%10C(C)C)=O)=O)=O)=O)NC%12=O)N
Biological Activity: Huwentoxin XVI, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC50 of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels[1].
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Huwentoxin XVI | Huwentoxin XVI, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC50 of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels. | |||||||||||||||||||||
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