1604034-71-0
Chemical Structure
PF-05387252
- CAS No.: 1604034-71-0
- Formula:C25H27N5O2
- Molecular Weight:429.51
IUPAC Name: 2-methoxy-3-(3-(4-methylpiperazin-1-yl)propoxy)-11H-indolo[3,2-c]quinoline-9-carbonitrile
InChIKey: TZXDMYIAOPUXQC-UHFFFAOYSA-N
SMILES: N#CC1=CC2=C(C=C1)C3=C(C4=CC(OC)=C(C=C4N=C3)OCCCN5CCN(CC5)C)N2
Biological Activity: PF-05387252 is a potent and selective IRAK4 inhibitor with the activity of inhibiting endogenous TLR signaling pathways. PF-05387252 has shown anti-inflammatory activity in experimental models and may have potential clinical application value in inhibiting psoriasis. Although PF-05387252 and its related compounds have shown anti-inflammatory effects in animal models, their efficacy in inhibiting psoriasis has not yet been verified[1].
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PF-05387252 | PF-05387252 is a potent and selective IRAK4 inhibitor with the activity of inhibiting endogenous TLR signaling pathways. PF-05387252 has shown anti-inflammatory activity in experimental models and may have potential clinical application value in inhibiting psoriasis. Although PF-05387252 and its related compounds have shown anti-inflammatory effects in animal models, their efficacy in inhibiting psoriasis has not yet been verified. | |||||||||||||||||||||
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