160845-97-6
160845-97-6
Chemical Structure
RS67506 free base
- CAS No.: 160845-97-6
- Formula:C18H28ClN3O4S
- Molecular Weight:417.95
InChIKey: UATDVRSFFGFTAI-UHFFFAOYSA-N
SMILES: O=C(CCC1CCN(CC1)CCNS(=O)(C)=O)C2=CC(Cl)=C(C=C2OC)N
Biological Activity: RS67506 free base is a 5-HT4 receptor partial agonist. RS67506 free base activates Gs-coupled signaling, increases cAMP/PKA and CREB phosphorylation/nuclear translocation, and promotes enteric neuron survival, neurogenesis, and GFAP -positive glial cell proliferation. RS67506 free base can be used for research on enteric neuropathy and constipation[1][2][3][4][5][6][7].
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RS67506 free base | RS67506 free base is a 5-HT4 receptor partial agonist. RS67506 free base activates Gs-coupled signaling, increases cAMP/PKA and CREB phosphorylation/nuclear translocation, and promotes enteric neuron survival, neurogenesis, and GFAP -positive glial cell proliferation. RS67506 free base can be used for research on enteric neuropathy and constipation. | |||||||||||||||||||||
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References
- [1]. Liu MT, et al. 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Aug 05;29(31):9683-99.
- [2]. Cartolano MC, et al. Pulsatile urea excretion in Gulf toadfish: the role of circulating serotonin and additional 5-HT receptor subtypes. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2019 Oct;189(5):537-548.
- [3]. Belkind-Gerson J, et al. Colitis induces enteric neurogenesis through a 5-HT4-dependent mechanism. Inflammatory bowel diseases. 2015 Apr;21(4):870-8.
- [4]. Eglen RM, et al. Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. British journal of pharmacology. 1995 Aug;115(8):1387-92. [Content Brief]
- [5]. Ataka K, et al. Wood creosote prevents CRF-induced motility via 5-HT3 receptors in proximal and 5-HT4 receptors in distal colon in rats. Autonomic neuroscience : basic & clinical. 2007 May 30;133(2):136-45.
- [6]. Hotta R, et al. Delivery of enteric neural progenitors with 5-HT4 agonist-loaded nanoparticles and thermosensitive hydrogel enhances cell proliferation and differentiation following transplantation in vivo. Biomaterials. 2016 May;88:1-11.
- [7]. Nagakura Y, et al. The selective 5-hydroxytryptamine (5-HT)4-receptor agonist RS67506 enhances lower intestinal propulsion in mice. Japanese journal of pharmacology. 1997 Jun;74(2):209-12.
