1609655-35-7
Chemical Structure
JPC-3210
- CAS No.: 1609655-35-7
- Formula:C21H26F4N2O
- Molecular Weight:398.44
IUPAC Name: 4-(tert-butyl)-2-((tert-butylamino)methyl)-6-(5-fluoro-6-(trifluoromethyl)pyridin-3-yl)phenol
InChIKey: DYULPLHABFGTOQ-UHFFFAOYSA-N
SMILES: OC1=C(C2=CC(F)=C(C(F)(F)F)N=C2)C=C(C(C)(C)C)C=C1CNC(C)(C)C
Biological Activity: JPC-3210 is an orally active aminomethylphenol. JPC-3210 exhibits anti-malarial activity with a mean IC50 ranging from 2.5 to 19 nM. JPC-3210 works by inhibiting the hemoglobin digestion pathway and promoting regulators of protein translation. JPC-3210 can inhibit CYP2D6 and CYP3A4 isozymes. JPC-3210 suppresses P. berghei infection in mice model. JPC-3210 possesses prophylactic protection in vivo. JPC-3210 can be studied in research on malaria prevention[1][2][3].
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JPC-3210 | JPC-3210 is an orally active aminomethylphenol. JPC-3210 exhibits anti-malarial activity with a mean IC50 ranging from 2.5 to 19 nM. JPC-3210 works by inhibiting the hemoglobin digestion pathway and promoting regulators of protein translation. JPC-3210 can inhibit CYP2D6 and CYP3A4 isozymes. JPC-3210 suppresses P. berghei infection in mice model. JPC-3210 possesses prophylactic protection in vivo. JPC-3210 can be studied in research on malaria prevention. | |||||||||||||||||||||
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References
- [1]. Birrell, G. W., et al., (2020). Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum. Molecular & cellular proteomics : MCP, 19(2), 308-325. [Content Brief]
- [2]. Birrell, G. W., et al., (2018). Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention. Antimicrobial agents and chemotherapy, 62(4), e01335-17. [Content Brief]
- [3]. Chavchich, M., et al., (2016). Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention. Antimicrobial agents and chemotherapy, 60(5), 3115-3118. [Content Brief]
