161262-45-9
Chemical Structure
Amotosalen hydrochloride
Synonym(s): S-59
- CAS No.: 161262-45-9
- Formula:C17H20ClNO4
- Molecular Weight:337.80
IUPAC Name: 3-((2-aminoethoxy)methyl)-2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one hydrochloride
InChIKey: MHLAMQBABOJZQW-UHFFFAOYSA-N
SMILES: NCCOCC(C1=CC(C(C)=C2)=C3OC2=O)=C(OC1=C3C)C.[H]Cl
Biological Activity: Amotosalen hydrochloride (S-59) is a light-activated, DNA-, RNA-crosslinking psoralen compound, which is used to neutralise pathogens. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells. Amotosalen can be used for the study of blood system pathogen reduction technology and graft-versus-host disease (GVHD)[1][2].
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Amotosalen hydrochloride | 99.86% | Amotosalen hydrochloride (S-59) is a light-activated, DNA-, RNA-crosslinking psoralen compound, which is used to neutralise pathogens. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells. Amotosalen can be used for the study of blood system pathogen reduction technology and graft-versus-host disease (GVHD). | ||||||||||||||||||||
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Amotosalen hydrochloride (Standard) | Amotosalen hydrochloride (Standard) (S-59 (Standard)) is the analytical standard of Amotosalen (hydrochloride) (HY-107004A). This product is intended for research and analytical applications. Amotosalen hydrochloride (S-59) is a light-activated, DNA-, RNA-crosslinKing psoralen compound, which is used to neutralise pathogens. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells. Amotosalen can be used for the study of blood system pathogen reduction technology and graft-versus-host disease (GVHD). | |||||||||||||||||||||
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References
- [1]. Amotosalen: Allogeneic Cellular Immunotherapies system, INTERCEPT Plasma System, INTERCEPT Platelet System, S 59. BioDrugs. 2003;17(1):66-8. [Content Brief]
- [2]. Lanteri MC, et al. Inactivation of a broad spectrum of viruses and parasites by photochemical treatment of plasma and platelets using amotosalen and ultraviolet A light. Transfusion. 2020 Jun;60(6):1319-1331. [Content Brief]
