1613078-24-2
Chemical Structure
Antiproliferative agent-61
- CAS No.: 1613078-24-2
- Formula:C22H18N2O3
- Molecular Weight:358.39
IUPAC Name: (E)-1-(3,4-dimethoxyphenyl)-3-(9H-pyrido[3,4-b]indol-1-yl)prop-2-en-1-one
InChIKey: ZWEQPXSQLZNQEM-CMDGGOBGSA-N
SMILES: O=C(/C=C/C1=NC=CC2=C1NC3=C2C=CC=C3)C4=CC=C(C(OC)=C4)OC
Biological Activity: Antiproliferative agent-61 is a synthetic β-carlinyl chalcone with significant antiproliferative activity. Antiproliferative agent-61 showed significant effects in a range of solid tumor cell lines, with the most prominent effects in breast cancer. Antiproliferative agent-61 showed IC50 values of 2.25 and 3.29 μM in the human breast cancer MCF-7 cell line. Antiproliferative agent-61 significantly induced DNA fragmentation and apoptosis in breast cancer cells. Antiproliferative agent-61 inhibited the interaction of MDM2 with p53 and promoted the degradation of MDM2[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Antiproliferative agent-61 | 98.93% | Antiproliferative agent-61 is a synthetic β-carlinyl chalcone with significant antiproliferative activity. Antiproliferative agent-61 showed significant effects in a range of solid tumor cell lines, with the most prominent effects in breast cancer. Antiproliferative agent-61 showed IC50 values of 2.25 and 3.29 μM in the human breast cancer MCF-7 cell line. Antiproliferative agent-61 significantly induced DNA fragmentation and apoptosis in breast cancer cells. Antiproliferative agent-61 inhibited the interaction of MDM2 with p53 and promoted the degradation of MDM2. | ||||||||||||||||||||
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