2. Apoptosis
  3. Apoptosis
  4. Antiproliferative agent-61

Antiproliferative agent-61 is a synthetic β-carlinyl chalcone with significant antiproliferative activity. Antiproliferative agent-61 showed significant effects in a range of solid tumor cell lines, with the most prominent effects in breast cancer. Antiproliferative agent-61 showed IC50 values of 2.25 and 3.29 μM in the human breast cancer MCF-7 cell line. Antiproliferative agent-61 significantly induced DNA fragmentation and apoptosis in breast cancer cells. Antiproliferative agent-61 inhibited the interaction of MDM2 with p53 and promoted the degradation of MDM2.

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Antiproliferative agent-61

Antiproliferative agent-61 Chemical Structure

CAS No. : 1613078-24-2

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Antiproliferative agent-61 Related Antibodies

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Description

Antiproliferative agent-61 is a synthetic β-carlinyl chalcone with significant antiproliferative activity. Antiproliferative agent-61 showed significant effects in a range of solid tumor cell lines, with the most prominent effects in breast cancer. Antiproliferative agent-61 showed IC50 values of 2.25 and 3.29 μM in the human breast cancer MCF-7 cell line. Antiproliferative agent-61 significantly induced DNA fragmentation and apoptosis in breast cancer cells. Antiproliferative agent-61 inhibited the interaction of MDM2 with p53 and promoted the degradation of MDM2[1].

Cellular Effect
Cell Line Type Value Description References
A 172 IC50
3.33 μM
Compound: 7c
Cytotoxicity against human A172 cells after 48 hrs by SRB assay
Cytotoxicity against human A172 cells after 48 hrs by SRB assay
[PMID: 24844196]
A549 IC50
2.31 μM
Compound: 7c
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
[PMID: 24844196]
DLD-1 IC50
2.5 μM
Compound: 26
Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
[PMID: 32531682]
MCF7 IC50
1.25 μM
Compound: 26
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
[PMID: 32531682]
MCF7 IC50
2.25 μM
Compound: 7c
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
[PMID: 24844196]
PC-3 IC50
5.99 μM
Compound: 7c
Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
[PMID: 24844196]
SK-OV-3 IC50
5 μM
Compound: 26
Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
[PMID: 32531682]
SK-OV-3 IC50
> 10 μM
Compound: 7c
Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
[PMID: 24844196]
SW-620 IC50
10 μM
Compound: 26
Cytotoxicity against human SW620 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
Cytotoxicity against human SW620 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
[PMID: 32531682]
Vero IC50
> 10 μM
Compound: 7c
Cytotoxicity against African green monkey Vero cells after 48 hrs by SRB assay
Cytotoxicity against African green monkey Vero cells after 48 hrs by SRB assay
[PMID: 24844196]
Molecular Weight

358.39

Formula

C22H18N2O3
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(/C=C/C1=NC=CC2=C1NC3=C2C=CC=C3)C4=CC=C(C(OC)=C4)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Antiproliferative agent-61 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-611613078-24-2Antiproliferative agent61Antiproliferative agent 61ApoptosisInhibitorinhibitorinhibit

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