Antiproliferative agent-61
Based on 1 Customer Validation
Antiproliferative agent-61 is a synthetic β-carlinyl chalcone with significant antiproliferative activity. Antiproliferative agent-61 showed significant effects in a range of solid tumor cell lines, with the most prominent effects in breast cancer. Antiproliferative agent-61 showed IC50 values of 2.25 and 3.29 μM in the human breast cancer MCF-7 cell line. Antiproliferative agent-61 significantly induced DNA fragmentation and apoptosis in breast cancer cells. Antiproliferative agent-61 inhibited the interaction of MDM2 with p53 and promoted the degradation of MDM2.
For research use only. We do not sell to patients.
- Purity: 98.93%
- CAS No.: 1613078-24-2
- Formula: C22H18N2O3
- Molecular Weight:358.39
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A 172 | IC50 |
3.33 μM
Compound: 7c
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Cytotoxicity against human A172 cells after 48 hrs by SRB assay
Cytotoxicity against human A172 cells after 48 hrs by SRB assay
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[PMID: 24844196] |
| A549 | IC50 |
2.31 μM
Compound: 7c
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Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
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[PMID: 24844196] |
| DLD-1 | IC50 |
2.5 μM
Compound: 26
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Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
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[PMID: 32531682] |
| MCF7 | IC50 |
1.25 μM
Compound: 26
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
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[PMID: 32531682] |
| MCF7 | IC50 |
2.25 μM
Compound: 7c
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Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
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[PMID: 24844196] |
| PC-3 | IC50 |
5.99 μM
Compound: 7c
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Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
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[PMID: 24844196] |
| SK-OV-3 | IC50 |
>10 μM
Compound: 7c
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Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
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[PMID: 24844196] |
| SK-OV-3 | IC50 |
5 μM
Compound: 26
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Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
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[PMID: 32531682] |
| SW-620 | IC50 |
10 μM
Compound: 26
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Cytotoxicity against human SW620 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
Cytotoxicity against human SW620 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
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[PMID: 32531682] |
| Vero | IC50 |
>10 μM
Compound: 7c
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Cytotoxicity against African green monkey Vero cells after 48 hrs by SRB assay
Cytotoxicity against African green monkey Vero cells after 48 hrs by SRB assay
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[PMID: 24844196] |
Chemical Information
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CAS No. 1613078-24-2
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Appearance Solid
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Molecular Weight 358.39
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Formula C22H18N2O3
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Color Yellow to orange
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SMILES
O=C(/C=C/C1=NC=CC2=C1NC3=C2C=CC=C3)C4=CC=C(C(OC)=C4)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (279.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7903 mL | 13.9513 mL | 27.9026 mL | 69.7564 mL |
| 5 mM | 0.5581 mL | 2.7903 mL | 5.5805 mL | 13.9513 mL | |
| 10 mM | 0.2790 mL | 1.3951 mL | 2.7903 mL | 6.9756 mL | |
| 15 mM | 0.1860 mL | 0.9301 mL | 1.8602 mL | 4.6504 mL | |
| 20 mM | 0.1395 mL | 0.6976 mL | 1.3951 mL | 3.4878 mL | |
| 25 mM | 0.1116 mL | 0.5581 mL | 1.1161 mL | 2.7903 mL | |
| 30 mM | 0.0930 mL | 0.4650 mL | 0.9301 mL | 2.3252 mL | |
| 40 mM | 0.0698 mL | 0.3488 mL | 0.6976 mL | 1.7439 mL | |
| 50 mM | 0.0558 mL | 0.2790 mL | 0.5581 mL | 1.3951 mL | |
| 60 mM | 0.0465 mL | 0.2325 mL | 0.4650 mL | 1.1626 mL | |
| 80 mM | 0.0349 mL | 0.1744 mL | 0.3488 mL | 0.8720 mL | |
| 100 mM | 0.0279 mL | 0.1395 mL | 0.2790 mL | 0.6976 mL |
Antiproliferative agent-61 Related Classifications
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