162705-07-9
162705-07-9
Chemical Structure
AVE-8063
Synonym(s): AC-7739 free base
- CAS No.: 162705-07-9
- Formula:C18H21NO4
- Molecular Weight:315.37
IUPAC Name: (Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)aniline
InChIKey: QSAMWSFELUCKOA-WAYWQWQTSA-N
SMILES: O(C)C1=C(OC)C=C(/C=C\C2=CC(N)=C(OC)C=C2)C=C1OC
Biological Activity: AVE-8063 (AC-7739 free base) is an aminocombretastatin. AVE-8063 shows potent antitubulin activity and cytotoxicity. AVE-8063 can be used in the research of leukemia and breast cancer[1][2].
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AVE-8063 | 97.04% | AVE-8063 (AC-7739 free base) is an aminocombretastatin. AVE-8063 shows potent antitubulin activity and cytotoxicity. AVE-8063 can be used in the research of leukemia and breast cancer. | ||||||||||||||||||||
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References
- [1]. Kamal A, et al. Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers. Bioorg Med Chem. 2014 Oct 1;22(19):5155-67. [Content Brief]
- [2]. Lee J, et al. Discovery of a potent tubulin polymerization inhibitor: synthesis and evaluation of water-soluble prodrugs of benzophenone analog. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6327-30. [Content Brief]
Keywords
