1630202-02-6
1630202-02-6
Chemical Structure
TOP1288
- CAS No.: 1630202-02-6
- Formula:C43H49N7O9S
- Molecular Weight:839.96
InChIKey: FWXVGKSWZJEPQI-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(C(C)(C)C)=CC(NS(=O)(C)=O)=C1OC)NC2=CC=C(C3=C2C=CC=C3)OC4=NC(NC5=CC(C#C)=CC(C(NCCOCCOCCOC)=O)=C5)=NC=C4
Biological Activity: TOP1288 is a narrow spectrum kinase inhibitor for P38α, Src and Syk kinase, with IC50 of 116nM, 24nM and 659nM, respectively. TOP1288 inhibits inflammatory cytokine release from inflamed biopsies and myofibroblasts[1].
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TOP1288 | TOP1288 is a narrow spectrum kinase inhibitor for P38α, Src and Syk kinase, with IC50 of 116nM, 24nM and 659nM, respectively. TOP1288 inhibits inflammatory cytokine release from inflamed biopsies and myofibroblasts. | |||||||||||||||||||||
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Keywords
