1637434-72-0
Chemical Structure
Acrizanib hydrochloride
Synonym(s): LHA510 hydrochloride
- CAS No.: 1637434-72-0
- Formula:C20H19ClF3N7O2
- Molecular Weight:481.86
IUPAC Name: N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide hydrochloride
InChIKey: LUWPLUJLLJFKEN-UHFFFAOYSA-N
SMILES: O=C(N1C=CC2=C1C=CC(OC3=NC=NC(CNC)=C3)=C2)NC4=NN(C)C(C(F)(F)F)=C4.Cl
Biological Activity: Acrizanib hydrochloride (LHA510 hydrochloride) is a small-molecule vascular endothelial growth factor receptor 2 (VEGFR-2, KDR) inhibitor. Acrizanib hydrochloride inhibits the proliferation of BaF3-Tel-KDR cells dependent on VEGFR-2 activity, with an IC50 of 17.4 nM. Acrizanib hydrochloride can be used in research related to choroidal neovascularization and neovascular age-related macular degeneration[1].
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Acrizanib hydrochloride | Acrizanib hydrochloride (LHA510 hydrochloride) is a small-molecule vascular endothelial growth factor receptor 2 (VEGFR-2, KDR) inhibitor. Acrizanib hydrochloride inhibits the proliferation of BaF3-Tel-KDR cells dependent on VEGFR-2 activity, with an IC50 of 17.4 nM. Acrizanib hydrochloride can be used in research related to choroidal neovascularization and neovascular age-related macular degeneration. | |||||||||||||||||||||
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References
- [1]. Adams CM, et al. The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration. J Med Chem. 2018 Feb 22;61(4):1622-1635. [Content Brief]
