1645260-76-9
Chemical Structure
DA-6886 monohydrochloride
- CAS No.: 1645260-76-9
- Formula:C19H28Cl2N6O2
- Molecular Weight:443.37
IUPAC Name: N-((1-(3-(1H-1,2,3-triazol-1-yl)propyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide hydrochloride
InChIKey: JPPDVIYHBBLDDI-UHFFFAOYSA-N
SMILES: O=C(NCC1CCN(CCCN2N=NC=C2)CC1)C3=CC(Cl)=C(N)C=C3OC.Cl
Biological Activity: DA-6886 is a 5-Hydroxytryptamine receptor 4 (5-HT4) agonist. DA-6886 induces relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels reveals that it inhibits hERG channel current with an pIC50 value of 4.3, indicating that the compound is 1000-fold more selective for the 5-HT4 receptor over hERG channels. DA-6886 can be used in the study of constipated irritable bowel syndrome[1][2].
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DA-6886 monohydrochloride | DA-6886 is a 5-Hydroxytryptamine receptor 4 (5-HT4) agonist. DA-6886 induces relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels reveals that it inhibits hERG channel current with an pIC50 value of 4.3, indicating that the compound is 1000-fold more selective for the 5-HT4 receptor over hERG channels. DA-6886 can be used in the study of constipated irritable bowel syndrome. | |||||||||||||||||||||
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- [1]. Lee D Y, et al. Pharmacokinetics of DA-6886, a new 5-HT4 receptor agonist, in rats[J]. Pharmaceutics, 2022, 14(4): 702. [Content Brief]
- [2]. Lee M J, et al. Pharmacological profile of DA-6886, a novel 5-HT4 receptor agonist to accelerate colonic motor activity in mice[J]. European Journal of Pharmacology, 2014, 735: 115-122. [Content Brief]
Keywords
