1668-13-9
Chemical Structure
H-Ala-pNA
- CAS No.: 1668-13-9
- Formula:C9H11N3O3
- Molecular Weight:209.20
IUPAC Name: (S)-2-amino-N-(4-nitrophenyl)propanamide
InChIKey: PXFUDSMGEYRNNC-LURJTMIESA-N
SMILES: C[C@H](N)C(NC1=CC=C(C=C1)N(=O)=O)=O
Biological Activity: H-Ala-pNA is an L-amino acid p-nitroaniline (pNA) derivative and a specific substrate for leukotriene A4 hydrolase. The D-enantiomer of H-Ala-pNA shows no activity toward leukotriene A4 hydrolase. H-Ala-pNA can be catalytically hydrolyzed by leukotriene A4 hydrolase, and the p-nitroaniline produced during the reaction is monitored spectrophotometrically at 405 nm to enable quantitative detection of enzyme activity. H-Ala-pNA is used to evaluate the potency of inhibitors targeting the amidase activity of leukotriene A4 hydrolase[1].
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H-Ala-pNA | H-Ala-pNA is an L-amino acid p-nitroaniline (pNA) derivative and a specific substrate for leukotriene A4 hydrolase. The D-enantiomer of H-Ala-pNA shows no activity toward leukotriene A4 hydrolase. H-Ala-pNA can be catalytically hydrolyzed by leukotriene A4 hydrolase, and the p-nitroaniline produced during the reaction is monitored spectrophotometrically at 405 nm to enable quantitative detection of enzyme activity. H-Ala-pNA is used to evaluate the potency of inhibitors targeting the amidase activity of leukotriene A4 hydrolase. | |||||||||||||||||||||
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