170294-35-6
Chemical Structure
Tyrosinase (192-200), human mouse
- CAS No.: 170294-35-6
- Formula:C54H77N13O17
- Molecular Weight:1180.27
IUPAC Name: tert-butyl (R)-3-hydroxy-1-oxo-8-azaspiro[4.5]decane-8-carboxylate
InChIKey: NRRPZMKRXAXQKT-XZUCTAAISA-N
SMILES: OC[C@H](N)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(N[C@H](C(O)=O)CC1=CC=CC=C1)=O)=O)=O)=O)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O
Biological Activity: Tyrosinase (192-200), human mouse is a HLA-B*4403-restricted tyrosinase epitope with affinity for HLA-B4403 and HLA-B4402. Tyrosinase (192-200), human mouse binds to HLA-B*4403 to form a complex, which is recognized by the autologous cytotoxic T lymphocyte clone 22/31 derived from melanoma. Tyrosinase (192-200), human mouse binds to HLA-B4402 to form a complex, which is recognized by the CTL clone 329B/5 derived from healthy HLA-B4402 donors. Tyrosinase (192-200), human mouse is applicable to melanoma-related research[1][2].
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Tyrosinase (192-200), human mouse | Tyrosinase (192-200), human mouse is a HLA-B*4403-restricted tyrosinase epitope with affinity for HLA-B4403 and HLA-B4402. Tyrosinase (192-200), human mouse binds to HLA-B*4403 to form a complex, which is recognized by the autologous cytotoxic T lymphocyte clone 22/31 derived from melanoma. Tyrosinase (192-200), human mouse binds to HLA-B4402 to form a complex, which is recognized by the CTL clone 329B/5 derived from healthy HLA-B4402 donors. Tyrosinase (192-200), human mouse is applicable to melanoma-related research. | |||||||||||||||||||||
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References
- [1]. Brichard VG, et al. A tyrosinase nonapeptide presented by HLA-B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes. Eur J Immunol. 1996;26(1):224-230. [Content Brief]
- [2]. Akatsuka Y, et al. Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens. J Exp Med. 2003;197(11):1489-1500. [Content Brief]
