1710337-31-7
Chemical Structure
GS-493
- CAS No.: 1710337-31-7
- Formula:C21H14N6O8S
- Molecular Weight:510.44
IUPAC Name: (Z)-4-(2-(1,3-bis(4-nitrophenyl)-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)benzenesulfonic acid
InChIKey: PKMKFRACKIHNRN-ATJXCDBQSA-N
SMILES: O=S(C1=CC=C(N/N=C2C(C3=CC=C([N+]([O-])=O)C=C3)=NN(C4=CC=C([N+]([O-])=O)C=C4)C/2=O)C=C1)(O)=O
Biological Activity: GS-493 is a selective protein tyrosine phosphatase SHP2 (PTPN11) inhibitor with an IC50 of 71 nM. GS-493 is 29- and 45-fold more active toward SHP2 than related SHP1 and PTP1B. GS-493 blocks cellular motility and growth of cancer cells. Antitumor activity[1].
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GS-493 | GS-493 is a selective protein tyrosine phosphatase SHP2 (PTPN11) inhibitor with an IC50 of 71 nM. GS-493 is 29- and 45-fold more active toward SHP2 than related SHP1 and PTP1B. GS-493 blocks cellular motility and growth of cancer cells. Antitumor activity. | |||||||||||||||||||||
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Keywords
