173059-17-1
173059-17-1
Chemical Structure
Rec 15/2615 hydrochloride
- CAS No.: 173059-17-1
- Formula:C26H34ClN5O5
- Molecular Weight:532.03
IUPAC Name: 1-(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)-2-(2-isopropyl-6-methoxyphenoxy)ethan-1-one hydrochloride
InChIKey: YLPWNPUPMQZIKN-UHFFFAOYSA-N
SMILES: CC(C1=C(OCC(N2CCN(C3=NC(N)=C4C=C(OC)C(OC)=CC4=N3)CC2)=O)C(OC)=CC=C1)C.[H]Cl
Biological Activity: Rec 15/2615 hydrochloride is a potent and selective α-1B adrenoceptor antagonist with Ki values of 1.9 nM, 0.3 nM, 2.6 nM for α1A, α1B, α1D, respectively. Rec 15/2615 hydrochloride modulates vaginal smooth muscle contractility and genital engorgement[1][2].
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Rec 15/2615 hydrochloride | Rec 15/2615 hydrochloride is a potent and selective α-1B adrenoceptor antagonist with Ki values of 1.9 nM, 0.3 nM, 2.6 nM for α1A, α1B, α1D, respectively. Rec 15/2615 hydrochloride modulates vaginal smooth muscle contractility and genital engorgement. | |||||||||||||||||||||
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References
- [1]. Bremner JB, et al. Ligand design for alpha1 adrenoceptor subtype selective antagonists. Bioorg Med Chem. 2000 Jan;8(1):201-14. [Content Brief]
- [2]. Kim NN, et al. Biochemical and functional characterization of alpha-adrenergic receptors in the rabbit vagina. Life Sci. 2002 Nov 1;71(24):2909-20. [Content Brief]
