173240-15-8
Chemical Structure
Nemifitide
Synonym(s): INN 00835
- CAS No.: 173240-15-8
- Formula:C33H43FN10O6
- Molecular Weight:694.77
IUPAC Name: (2S,4R)-N-((S)-1-((2-(((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-2-oxoethyl)amino)-5-guanidino-1-oxopentan-2-yl)-1-((S)-2-amino-3-(4-fluorophenyl)propanoyl)-4-hydroxypyrrolidine-2-carboxamide
InChIKey: SGXPTOACEHQGHL-RCNLLYRESA-N
SMILES: C([C@H](CC1=CC=C(F)C=C1)N)(=O)N2[C@H](C(N[C@H](C(NCC(N[C@@H](CC=3C=4C(NC3)=CC=CC4)C(N)=O)=O)=O)CCCNC(=N)N)=O)C[C@@H](O)C2
Biological Activity: Nemifitide (INN 00835) is a 5-HT2A receptor ligand that crosses the blood-brain barrier. Nemifitide is used in research related to major depressive disorder[1][2][3].
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Nemifitide | Nemifitide (INN 00835) is a 5-HT2A receptor ligand that crosses the blood-brain barrier. Nemifitide is used in research related to major depressive disorder. | |||||||||||||||||||||
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References
- [1]. Montgomery SA, et al. Efficacy and safety of 30 mg/d and 45 mg/d nemifitide compared to placebo in major depressive disorder. The international journal of neuropsychopharmacology. 2006 Oct;9(5):517-28. [Content Brief]
- [2]. Overstreet DH, et al. Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression. Psychopharmacology. 2004 Sep;175(3):303-9. [Content Brief]
- [3]. Feighner JP, et al. Clinical pharmacokinetic studies with INN 00835 (nemifitide), a novel pentapeptide antidepressant. Biopharmaceutics & drug disposition. 2002 Jan;23(1):33-9.
