17364-19-1
Chemical Structure
1-Stearoyl-lysophosphatidylcholine
Synonym(s): 18:0-LPC
- No. CAS: 17364-19-1
- Formula:C26H54NO7P
- Molecular Weight:523.69
IUPAC Name: 2-hydroxy-3-(stearoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
InChIKey: IHNKQIMGVNPMTC-UHFFFAOYSA-N
SMILES: O=C(OCC(O)COP(=O)([O-])OCC[N+](C)(C)C)CCCCCCCCCCCCCCCCC
Biological Activity: 1-Stearoyl-lysophosphatidylcholine (18:0-LPC) is a lysophosphatidylcholine generated by iPLA2β-mediated hydrolysis of phosphatidylcholine and present in circulating LDL; under different hydration conditions, it can form a bilayer gel phase, bilayer liquid crystalline phase, or micellar phase, and serves as a key metabolic node in the JSRV-induced OPA protein-metabolite network. 1-Stearoyl-lysophosphatidylcholine can be used in research on nonalcoholic steatohepatitis and ovine pulmonary adenocarcinoma[1][2][3][4][5].
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1-Stearoyl-lysophosphatidylcholine | 1-Stearoyl-lysophosphatidylcholine (18:0-LPC) is a lysophosphatidylcholine generated by iPLA2β-mediated hydrolysis of phosphatidylcholine and present in circulating LDL; under different hydration conditions, it can form a bilayer gel phase, bilayer liquid crystalline phase, or micellar phase, and serves as a key metabolic node in the JSRV-induced OPA protein-metabolite network. 1-Stearoyl-lysophosphatidylcholine can be used in research on nonalcoholic steatohepatitis and ovine pulmonary adenocarcinoma. | |||||||||||||||||||||
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References
- [1]. Otto AC, et al. Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2019 May;1864(5):662-676.
- [2]. Lee MW, et al. Characterization of a partially purified diacylglycerol lipase from bovine aorta. Biochimica et biophysica acta. 1995 Feb 09;1254(3):311-8.
- [3]. Shah J, et al. Structure and thermotropic properties of 1-stearoyl-2-acetyl-phosphatidylcholine bilayer membranes. Biophysical journal. 1994 May;66(5):1469-78.
- [4]. Zhang P, et al. Integrated Proteomic and Metabolomic Analyses Characterise Molecular Alterations Associated with JSRV-Induced OPA. Biology. 2026 Jun 23;15(13):982.
- [5]. Fortunato J, et al. Lipoprotein-associated phospholipase A₂ mass level is increased in elderly subjects with type 2 diabetes mellitus. Journal of diabetes research. 2014;2014:278063.
