173941-74-7
Chemical Structure
YM-44778
- CAS No.: 173941-74-7
- Formula:C34H39Cl2N3O5
- Molecular Weight:640.60
IUPAC Name: N-(2-(3,4-dichlorophenyl)-4-(3-oxo-3,4-dihydro-2H-spiro[isoquinoline-1,4'-piperidin]-1'-yl)butyl)-3,4,5-trimethoxy-N-methylbenzamide
InChIKey: RMRHFQVHSFCBEO-UHFFFAOYSA-N
SMILES: O=C(C1=CC(OC)=C(C(OC)=C1)OC)N(C)CC(CCN2CCC3(NC(CC4=C3C=CC=C4)=O)CC2)C5=CC=C(C(Cl)=C5)Cl
Biological Activity: YM-44778 is a neurokinin receptor antagonist. The pKi values for NK1, NK2 and NK3 are 8.08, 8.55 and 8.24, respectively. YM-44778 inhibits the increase of bladder pressure induced by substance [Sar9,Met(O2)11] -P (HY-P1012) in anestheticized rats[1].
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YM-44778 | YM-44778 is a neurokinin receptor antagonist. The pKi values for NK1, NK2 and NK3 are 8.08, 8.55 and 8.24, respectively. YM-44778 inhibits the increase of bladder pressure induced by substance [Sar9,Met(O2)11] -P (HY-P1012) in anestheticized rats. | |||||||||||||||||||||
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Keywords
