17479-06-0
Chemical Structure
UDP-Galactosamine
- CAS No.: 17479-06-0
- Formula:C15H25N3O16P2
- Molecular Weight:565.32
InChIKey: CYKLRRKFBPBYEI-KBQKSTHMSA-N
SMILES: O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)N)(O)=O)(O)=O)O2)NC1=O
Biological Activity: UDP-Galactosamine is a sugar nucleotide donor and enzyme substrate, exhibiting activity toward Galactosyltransferase, UDP-galactose 4'-epimerase, and hexose-1-phosphate uridylyltransferase. UDP-Galactosamine supports the transfer of galactosamine residues to acceptor molecules and participates in the biosynthesis of UDP-galactose. UDP-Galactosamine enables a two-step chemoenzymatic preparative-scale synthesis of GalNAc-glycosides and derivatives with unnatural glycosidic linkages [1][2].
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UDP-Galactosamine | UDP-Galactosamine is a sugar nucleotide donor and enzyme substrate, exhibiting activity toward Galactosyltransferase, UDP-galactose 4'-epimerase, and hexose-1-phosphate uridylyltransferase. UDP-Galactosamine supports the transfer of galactosamine residues to acceptor molecules and participates in the biosynthesis of UDP-galactose. UDP-Galactosamine enables a two-step chemoenzymatic preparative-scale synthesis of GalNAc-glycosides and derivatives with unnatural glycosidic linkages . | |||||||||||||||||||||
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References
- [1]. Fu X, et al. General Tolerance of Galactosyltransferases toward UDP-galactosamine Expands Their Synthetic Capability. Angew Chem Int Ed Engl. 2021;60(51):26555-26560.
- [2]. Rodríguez-Díaz J, et al. Regulatory insights into the production of UDP-N-acetylglucosamine by Lactobacillus casei. Bioengineered. 2012;3(6):339-342.
