17482-37-0
Chemical Structure
Amentoflavone hexaacetate
- CAS No.: 17482-37-0
- Formula:C42H30O16
- Molecular Weight:790.68
IUPAC Name: 2-(4-acetoxy-3-(5,7-diacetoxy-2-(4-acetoxyphenyl)-4-oxo-4H-chromen-8-yl)phenyl)-4-oxo-4H-chromene-5,7-diyl diacetate
InChIKey: ZOWFPOHSDODQAG-UHFFFAOYSA-N
SMILES: O=C1C=C(OC2=C(C(OC(C)=O)=CC(OC(C)=O)=C12)C3=CC(C4=CC(C5=C(C=C(C=C5O4)OC(C)=O)OC(C)=O)=O)=CC=C3OC(C)=O)C6=CC=C(C=C6)OC(C)=O
Biological Activity: Amentoflavone hexaacetate is a 3,5-cyclic nucleotide phosphodiesterase inhibitor with antiplatelet aggregation activity. Amentoflavone hexaacetate can inhibit the aggregation of eluted human platelets induced by ADP or collagen. Amentoflavone hexaacetate can also inhibit the cAMP phosphodiesterase activity in human platelets. Amentoflavone hexaacetate can significantly increase the cAMP level of platelets in the presence of prostaglandin E1. Amentoflavone hexaacetate has anti-angiogenic and anti-metastatic effects[1].
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Amentoflavone hexaacetate | Amentoflavone hexaacetate is a 3,5-cyclic nucleotide phosphodiesterase inhibitor with antiplatelet aggregation activity. Amentoflavone hexaacetate can inhibit the aggregation of eluted human platelets induced by ADP or collagen. Amentoflavone hexaacetate can also inhibit the cAMP phosphodiesterase activity in human platelets. Amentoflavone hexaacetate can significantly increase the cAMP level of platelets in the presence of prostaglandin E1. Amentoflavone hexaacetate has anti-angiogenic and anti-metastatic effects. | |||||||||||||||||||||
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Keywords
