175097-37-7
Chemical Structure
WRC-0571
- CAS No.: 175097-37-7
- Formula:C17H26N6O
- Molecular Weight:330.43
IUPAC Name: (1R,2R,4R,5R)-5-((8-(isopropyl(methyl)amino)-9-methyl-9H-purin-6-yl)amino)bicyclo[2.2.1]heptan-2-ol
InChIKey: FTVZUYADPTUEKI-FDYHWXHSSA-N
SMILES: CC(C)N(C)C1=NC(C(N[C@H]2[C@@H]3C[C@@H]([C@H](O)C3)C2)=NC=N4)=C4N1C
Biological Activity: WRC-0571 is an orally effective, potent, and selective non-xanthine adenosine A1 receptor antagonist with a Ki value of 1.7 nM for the human A1 receptor. WRC-0571 competitively binds to and blocks adenosine A1 receptor, thereby inhibiting downstream signaling and physiological responses. WRC-0571 can be used for research on bradycardia[1][2][3].
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WRC-0571 | WRC-0571 is an orally effective, potent, and selective non-xanthine adenosine A1 receptor antagonist with a Ki value of 1.7 nM for the human A1 receptor. WRC-0571 competitively binds to and blocks adenosine A1 receptor, thereby inhibiting downstream signaling and physiological responses. WRC-0571 can be used for research on bradycardia. | |||||||||||||||||||||
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References
- [1]. Jin X, et al. Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation. The Journal of clinical investigation. 1997 Dec 01;100(11):2849-57.
- [2]. Gao Z, et al. A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis. Mol Pharmacol. 2001;59(1):76-82.
