1765-93-1
Chemical Structure
4-Fluorobenzeneboronic acid
Synonym(s): P-Fluorophenylboronic acid
- CAS No.: 1765-93-1
- Formula:C6H6BFO2
- Molecular Weight:139.92
IUPAC Name: (4-fluorophenyl)boronic acid
InChIKey: LBUNNMJLXWQQBY-UHFFFAOYSA-N
SMILES: FC1=CC=C(B(O)O)C=C1
Biological Activity: 4-Fluorobenzeneboronic acid (P-Fluorophenylboronic acid) is a fluorinated arylboronic acid coupling ligand and precursor. Under the catalysis of heterogeneous palladium nanoparticles, 4-Fluorobenzeneboronic acid participates in the Suzuki-Miyaura C-C coupling reaction to generate fluorinated biphenyl derivatives. 4-Fluorobenzeneboronic acid also participates in the copper-catalyzed three-component reaction with nitrobenzene and potassium metabisulfite as substrates, and finally produces sulfonamides through the formation of arylsulfinate intermediates, copper-assisted S-N bond construction and reduction steps[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-Fluorobenzeneboronic acid | 98.0% | 4-Fluorobenzeneboronic acid (P-Fluorophenylboronic acid) is a fluorinated arylboronic acid coupling ligand and precursor. Under the catalysis of heterogeneous palladium nanoparticles, 4-Fluorobenzeneboronic acid participates in the Suzuki-Miyaura C-C coupling reaction to generate fluorinated biphenyl derivatives. 4-Fluorobenzeneboronic acid also participates in the copper-catalyzed three-component reaction with nitrobenzene and potassium metabisulfite as substrates, and finally produces sulfonamides through the formation of arylsulfinate intermediates, copper-assisted S-N bond construction and reduction steps. | ||||||||||||||||||||
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References
- [1]. Erami R S, et al. Suzuki-Miyaura CC coupling reactions catalyzed by supported Pd nanoparticles for the preparation of fluorinated biphenyl derivatives[J]. Catalysts, 2017, 7(3): 76.
- [2]. Wang X, et al. Copper-catalyzed synthesis of sulfonamides from nitroarenes via the insertion of sulfur dioxide. Chemical communications (Cambridge, England). 2020 Mar 19;56(23):3437-3440.
