1781834-82-9
1781834-82-9
Chemical Structure
PSN 375963 hydrochloride
- CAS No.: 1781834-82-9
- Formula:C17H24ClN3O
- Molecular Weight:321.84
IUPAC Name: 5-(4-butylcyclohexyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole hydrochloride
InChIKey: ONDLSENXTCSHGC-UHFFFAOYSA-N
SMILES: CCCCC1CCC(C2=NC(C3=CC=NC=C3)=NO2)CC1.[H]Cl
Biological Activity: PSN 375963 hydrochloride is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 hydrochloride shows similar potency to the endogenous agonist oleoylethanolamide (OEA)[1][2].
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PSN 375963 hydrochloride | PSN 375963 hydrochloride is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 hydrochloride shows similar potency to the endogenous agonist oleoylethanolamide (OEA). | |||||||||||||||||||||
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References
- [1]. Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3(3):167-175. [Content Brief]
- [2]. Ning Y, et al. Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br J Pharmacol. 2008;155(7):1056-1065. [Content Brief]
Keywords
