178970-88-2
Chemical Structure
Perforin-IN-3
- CAS No.: 178970-88-2
- Formula:C14H11NO3S
- Molecular Weight:273.31
IUPAC Name: (Z)-6-methyl-1-((5-methylfuran-2-yl)methylene)-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one
InChIKey: UCKLIUAJVINKBS-WDZFZDKYSA-N
SMILES: C(=C\1/C2=C(C(=O)O1)C(=S)NC(C)=C2)\C3=CC=C(C)O3
Biological Activity: Perforin-IN-3 is a specific perforin inhibitor that blocks perforin-mediated lytic pore formation and subsequent cell lysis. Perforin-IN-3 potently inhibits the killing effect of NK cells on target cells such as leukemia cells, without interfering with FasL- or TRAIL-mediated cell death pathways. Perforin-IN-3 has no effect on pneumolysin and can be used to study autoimmune diseases, allograft rejection, graft-versus-host disease, and familial hemophagocytic lymphohistiocytosis[1].
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Perforin-IN-3 | Perforin-IN-3 is a specific perforin inhibitor that blocks perforin-mediated lytic pore formation and subsequent cell lysis. Perforin-IN-3 potently inhibits the killing effect of NK cells on target cells such as leukemia cells, without interfering with FasL- or TRAIL-mediated cell death pathways. Perforin-IN-3 has no effect on pneumolysin and can be used to study autoimmune diseases, allograft rejection, graft-versus-host disease, and familial hemophagocytic lymphohistiocytosis. | |||||||||||||||||||||
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