180083-49-2
Chemical Structure
SB-236057
- CAS No.: 180083-49-2
- Formula:C33H34N4O3
- Molecular Weight:534.65
IUPAC Name: (1'-ethyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)(2'-methyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-[1,1'-biphenyl]-4-yl)methanone
InChIKey: WXAKEEQOWUHGCI-UHFFFAOYSA-N
SMILES: O=C(N1C2=CC3=C(C=C2CC1)OCC34CCN(CC4)CC)C5=CC=C(C6=C(C)C=C(C7=NN=C(C)O7)C=C6)C=C5
Biological Activity: SB-236057 is an inverse agonist of the 5-HT1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1. SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis[1].
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SB-236057 | SB-236057 is an inverse agonist of the 5-HT1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1. SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis. | |||||||||||||||||||||
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