1807320-40-6
Chemical Structure
FM04
- CAS No.: 1807320-40-6
- Formula:C26H25NO4
- Molecular Weight:415.48
IUPAC Name: 2-(4-(2-(2-(benzylamino)ethoxy)ethoxy)phenyl)-4H-chromen-4-one
InChIKey: JIFJFNBTQSCGBM-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=C(OCCOCCNCC3=CC=CC=C3)C=C2)OC4=C1C=CC=C4
Biological Activity: FM04 is a potent P-glycoprotein (P-gp) inhibitor (EC50=83 nM). FM04 inhibits P-gp in 2 mechanism: (1)FM04 binds to Q1193, followed by interacting with the functionally critical residues H1195 and T1226; or (2)FM04 binds to I1115 (a functionally critical residue itself), disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling ICL2-NBD2 interaction and thereby inhibiting P-gp[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FM04 | 99.86% | FM04 is a potent P-glycoprotein (P-gp) inhibitor (EC50=83 nM). FM04 inhibits P-gp in 2 mechanism: (1)FM04 binds to Q1193, followed by interacting with the functionally critical residues H1195 and T1226; or (2)FM04 binds to I1115 (a functionally critical residue itself), disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling ICL2-NBD2 interaction and thereby inhibiting P-gp. | ||||||||||||||||||||
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Keywords
