1815612-79-3
1815612-79-3
Chemical Structure
AAK1-IN-4
- CAS No.: 1815612-79-3
- Formula:C20H28N4O3
- Molecular Weight:372.46
IUPAC Name: methyl (S)-(5-((2-amino-2,4-dimethylpentyl)oxy)-6-methyl-[2,4'-bipyridin]-2'-yl)carbamate
InChIKey: HINOQCZIDBNXEI-FQEVSTJZSA-N
SMILES: CC(C[C@](N)(COC1=CC=C(C2=CC=NC(NC(OC)=O)=C2)N=C1C)C)C
Biological Activity: AAK1-IN-4 is a highly selective, CNS-penetrable, and orally active adaptor protein-2-associated kinase 1 (AAK1) inhibitor (AAK1 IC50 of 4.6 nM, Filt Ki of 0.9 nM, and cell IC50 of 8.6 nM). AAK1-IN-4 has the potential for the research for neuropathic pain[1].
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AAK1-IN-4 | AAK1-IN-4 is a highly selective, CNS-penetrable, and orally active adaptor protein-2-associated kinase 1 (AAK1) inhibitor (AAK1 IC50 of 4.6 nM, Filt Ki of 0.9 nM, and cell IC50 of 8.6 nM). AAK1-IN-4 has the potential for the research for neuropathic pain. | |||||||||||||||||||||
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References
Keywords
