1818253-48-3
Chemical Structure
(S,S)-TAK-418
- CAS No.: 1818253-48-3
- Formula:C17H25ClN2O2S
- Molecular Weight:356.91
InChIKey: LEEWMGOHGNRDKC-YYLIZZNMSA-N
SMILES: O=C(NC1CCOCC1)C2=CSC([C@@H](C3)[C@H]3NCC4CC4)=C2.Cl
Biological Activity: (S,S)-TAK-418 is a potent inhibitor of lysine-specific demethylase 1 (LSD1), demonstrating significant normalization of aberrant gene expression in neurodevelopmental disorders. (S,S)-TAK-418 also ameliorates ASD-like behaviors in rodent models affected by maternal exposure to valproate or poly I:C. (S,S)-TAK-418 modulates gene expression differently across various models and ages, indicating its potential as a therapeutic agent for conditions like autism spectrum disorder and schizophrenia.
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(S,S)-TAK-418 | (S,S)-TAK-418 is a potent inhibitor of lysine-specific demethylase 1 (LSD1), demonstrating significant normalization of aberrant gene expression in neurodevelopmental disorders. (S,S)-TAK-418 also ameliorates ASD-like behaviors in rodent models affected by maternal exposure to valproate or poly I:C. (S,S)-TAK-418 modulates gene expression differently across various models and ages, indicating its potential as a therapeutic agent for conditions like autism spectrum disorder and schizophrenia. | |||||||||||||||||||||
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Keywords
